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DERIVATIVES OF PYRROLO-PYRAZINES HAVING A KINASE INHIBITORY ACTIVITY AND THEIR BIOLOGICAL APPLICATIONS |
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Principal Investigator : L. Meijer
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TECHNICAL DESCRIPTION
Aloisines, are a new family of protein kinases inhibitors, proteins implied in the cellular cycle. The inventors characterized their anti-proliferative properties and optimized their formulation for an anti-cancer application, crystalline structures CDK2 and GSK-3/ Aloisine A having been obtained.
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