One of the major problems of conventional anti-cancer therapy lies in the effectively close similarity between many anti-cancer compounds which renders them susceptible to efflux by the ABC Transporters implicated in Multi-Drug Resistance. The calix[n]arenes are macrocyclic supramolecular platforms of variable size and functionality that are three-dimensional and hence are not associated with the structures of typical anti-cancer drugs. They may also be designed to specifically extract membrane proteins such as the ABC transporters from cell membranes and thus be vectorised against chemotherapeutically resistant cancers.