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USE OF PKS 13 PROTEIN CODING FOR CONDENSATION OF MYCOLIC ACIDS OF MYCOBACTERIA AND RELATED STRAINS AS AN ANTIBODY TARGET |
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Principal Investigator : C. Guilhot
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TECHNICAL DESCRIPTION
The invention relates to a novel enzyme involved in the biosynthesis of mycolic acids and to the use thereof for the screening of antibodies, especially antimycobacterials. The invention more particularly relates to the Pks13 protein which catalyzes Claisen condensation or malonic condensation in mycolates between an acyl-CoA molecule or an acyl-AMP molecule and an acylmalonyl-CoA molecule to form an intermediate ss-cEto acyl ou ss-cEto ester.
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