|
ASIC, A PROTON GATED CHANNEL |
|
Principal Investigator: M. LAZDUNSKI
|
TECHNICAL DESCRIPTION
The inventors have identified a new family of acid sensing ion channels detecting local acidosis and generating pain. They have isolated the gene and elucidated its functional activities. This molecule, ASIC, is a Mammalian neuronal acid sensing cationic channel and more specifically a proton activated sodium channel gated by H+ and mainly permeable to Na+. ASIC responds to acidity by generating an electric current which is then relayed towards the spinal cord and the brain.
Pour lire la suite, merci de vous identifier ou de vous inscrire dans la zone de droite... |
