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METHOD FOR COUPLING, IN SOLUTION, A PEPTIDE WITH AT LEAST ANOTHER COMPOUND AND USES THEREOF |
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Principal Investigator: O. MELNYK
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TECHNICAL DESCRIPTION
The invention concerns a method for coupling a peptide with at least a compound A, of the non-peptide type, bearing a function selected among the group consisting of carboxylic acid functions and alcohol functions.
The invention is characterised in that said coupling comprises a step which consists in producing, in solution, a hydrazide bond between said peptide and said compound A.
The invention also concerns modified peptides essentially formed by a peptide bound by a hydrazide bond to at least a compound A as defined above, such as a lipid, a sugar, an alcohol or a fluorescent marker, as well as the uses of said modified peptides.
The invention further concerns the use of N,N'-tri(Boc)hydrazinoacetic and N,N'-di(Boc)hydrazinoacetic acids to functionalize a peptide with a alpha -hydrazinoacetic group.
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