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New therapeutic strategies to improve anticancer treatment |
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Principal investigator : Isabelle Mus-Veteau
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CONTEXT
The Hedgehog
(Hh) pathway plays a crucial role in stem cell self-renewal and tissue
regeneration. Mutations that increase the overall activity of the pathway have
been shown to be involved in the development of tumours in the lung,
oesophagus, stomach, pancreas, biliary tract, breast, prostate, and brain. Many
of these tumours contain cancer stem cells which present an aberrant Hh pathway
activation and retain self-renewal properties representing a never-ending
reservoir for the maintenance of the tumour mass. These cells are resistant to
classical chemiotherapies because they express multidrug resistance proteins
that efflux chemiotherapeutic agents from the cells. We demonstrated that the
receptor of the Hh pathway Patched also contributes to the efflux of
chemiotherapeutic agents such as doxorubicine.
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