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New device for 3D cell culture of normal and cancer cells |
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Principal Investigator: Marie-Danielle NAGEL
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TECHNICAL DESCRIPTION
This invention describes a sterile cellulose-coated device for 3D culture of normal and cancer adherent cells. Cells in aggregates are induced to reduce their proliferation, synthesize proteins and differentiate, and/or enter into an apoptotic process.
This device is a research tool for:
-cell adhesion studies: matrix/cell relationships
-cell-cell communication studies
- research on cell proliferation, differentiation, apoptosis.
Results were obtained using:
-mouse Swiss 3T3 and L929 fibroblasts
-mouse MC 3T3 pre-osteoblasts
-mouse melanoma B16C3, B16 F0, B16 F1, B16F10
-human melanoma FO-1
-primary human melanoma cell culture
-mouse B16F10 melanoma explants
-human melanoma explants
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