CONTEXT

Many fluorinated compounds are known as medicaments, for example fluorocorticoids, such as flurbiprofen and niflumic acid. Glaucoma is an ocular disease that is very widespread among the world. It is the second cause of blindness in the world after cataracts. There is at present no means of curing glaucoma but only treatments intended to limit the progression of the disease.

Document EP 0 277 814 describes the use of trifluoromethanesulfomide and its pharmaceutically acceptable salts in the topical treatment of glaucoma. However the compound has the disadvantages of being highly toxic. In addition it is extremely acid and hence difficult for topical application to the eye.

It has been found that some fluorinated sulfamides and their derivatives have an inhibiting effect on metallo-enzymes that is comparable with, or even superior to, that of acetazolamide, while having a tolerable level of toxicity.