For the last three decades, the team headed by Richard Giegé at the Institute for Molecular and Cell Biology (IBMC, CNRS) in Strasbourg, has been actively involved in the development of methods and strategies that facilitate the production of crystals from biomolecules in the frame of structural biology studies. In 2004, Dr. Sauter initiated a multidisciplinary research that associated his team with two teams of physical-chemists experts in material science, microfabrication and microfluidics. The basic idea was to take advantage of the microfluidic technology to bypass the major difficulties encountered during biomolecule crystallization that is the most delicate and rate-limiting step of many structural biology projects.