The process of producing a microfluidic device by photo-assisted and/or thermally assisted printing, comprises printing a photo-curable and/or heat-curable liquid resin disposed on a support using a stamp made of an elastomeric material, photo-irradiating the resin through the stamp to form a profiled base and lateral sides of the device forming a first motif, and placing a lid on the profiled base and irradiating the device and the lid to seal the device.