CONTEXT

Alzheimer’s disease (AD) is the most common cause of dementia and affects around 27 millions people in the world. This disease is characterized by a progressive neurodegeneration leading to complete dependance of the patient, and has a major economic and societal impact in developed countries.

One of the hallmarks of AD is the accumulation of misfolded A-beta and Tau proteins. Tau is a microtubule-associated protein that stabilizes the neuron cytoskeleton, and especially axons. Upon AD onset, biochemical changes will induce Tau hyper-phosphorylation that cause its dissociation from microtubules leading to their disintegration, with consequence the neuronal loss-of-function.