|
POLYPEPETIDES DERIVATED FROM RETINOIC ACID-RELATED ORPHAN RECEPTOR (ROR) AND THEIR APPLICATIONS |
|
Principal Investigator : D. Moras
|
TECHNICAL DESCRIPTION
The invention relates to polypeptides derived from the retinoic acid-related orphan receptor (ROR) in mammals, characterized in that they are delimited in their N-terminal extremity by an amino-acid located between positions 1 to 209, and in their C-terminal extremity by an amino-acid located between positions 450 to 452 of the rat RORbeta , alpha , or gamma, or by an amino-acid located at corresponding positions in nuclear receptor ROR of other subtypes than alpha , beta and gamma, and/or of the other mammals. The invention also relates to the use of these polypeptides, or of the molecular complexes or the crystals containing them, for carrying out:--a process for the screening of a ROR-LBD ligand which is an agonist, or an antagonist of said receptor,--or a process for the analysis of the tridimensional structure of the complexes formed with said polypeptides, molecular complexes or crystals and a particular compound.
¡Para continuar la lectura conéctese ! au lieu de ¡Para leer la consecuencia, conectarse! |
