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ASIC, A PROTON GATED CHANNEL |
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Principal Investigator: M. LAZDUNSKI
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TECHNICAL DESCRIPTION
The inventors have identified a new family of acid sensing ion channels detecting local acidosis and generating pain. They have isolated the gene and elucidated its functional activities. This molecule, ASIC, is a Mammalian neuronal acid sensing cationic channel and more specifically a proton activated sodium channel gated by H+ and mainly permeable to Na+. ASIC responds to acidity by generating an electric current which is then relayed towards the spinal cord and the brain.
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