|
New therapeutic strategies involving Hedgeghog signaling pathway |
|
Principal investigator : Isabelle Mus-Veteau
|
|
CONTEXT
The Hedgehog
(Hh) pathway plays a crucial role during embryonic development. In adults,
recent studies suggest a role of this pathway in stem cell self-renewal and
tissue regeneration. Mutations that increase the overall activity of the
pathway have been shown to be involved in the development of tumours in the
lung, oesophagus, stomach, pancreas, biliary tract, breast, prostate, and
brain. Many of these tumours contain cancer stem cells which present an
aberrant Hh pathway activation and retain self-renewal properties representing
a never-ending reservoir for the maintenance of the tumour mass. The inhibition
of the signaling receptor Smoothened (Smo) by Patched (Ptc) is one of the most
affected steps of the Hh pathway in many tumours. Our findings suggest that Ptc
is involved in cholesterol efflux from the cells. This newly identified
function of Ptc could modulate Smo stabilization at the cell surface which is a
critical step of the Hh pathway activation.
¡Para continuar la lectura conéctese ! au lieu de ¡Para leer la consecuencia, conectarse! |
