CONTEXT

The diaryl ether structure is found in numerous important organic compounds in the pharmaceutical and polymer industries. The common synthesis of diaryl ethers usually requires the reaction of phenols with aryl halides in the presence of a catalyst containing a transition metal. It has been reported that Pd catalyzed methods can function in this role but their high costs and elaborate ligands are drawbacks when compared with copper mediated reactions. Indeed, in recent years much work has contributed to improving the traditional Ullmann ether synthesis which requires stoichiometric quantities of copper and harsh conditions. In spite of great advances in the use of copper catalysts associated with specific ligands, the aryl chlorides are still problematic substrates. Thus a convenient and general method for arylation from aryl chlorides should be of great interest to industrial production and laboratory research due to their low cost and ready availability.

We now report the first general method for copper catalyzed arylation of phenols from aryl chlorides. An additional finding of this study is the iron catalyzed arylation of phenols from aryl iodides.