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FIXATION OF AN ENANTIOSELECTIVE CATALYST ON A MAGNETIC SUPPORT |
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Principal Investigator: J. COURT
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TECHNICAL DESCRIPTION
A very efficient homogeneous catalytic system has been heterogenized without any loss of enantioselectivity. Actually 1,3,2-oxazaborolidines, chiral inductors in the enantioselective reduction of ketones into alcohols, are anchored on solids such as Raney nickel, Raney cobalt or Raney iron, which are widely used in industrial organic synthesis.
Separation between catalyst and reaction product is immediate. This essential feature is especially valuable when the ketone to be reduced contains an amine function or another basic function. Indeed, in the homogeneous process, separation between the ß-aminoalcohol and the product (alcohol) appears to be very difficult. The catalyst isolated from the reaction mixture is immediately recycled without any notable loss of enantioselectivity.
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