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4-(ARYLTHIO)-PYRIDIN-2(1H)-ONES: NEW DRUGS TO TREAT HIV DISEASES |
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Principal Investigator : E. BISAGNI
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TECHNICAL DESCRIPTION
Biological studies have shown that 4-(Arylthio)-pyridin-2(1H)-ones have potent HIV-1 specific reverse transcriptase inhibitory properties. These compounds decreased the number of virus products by the cell line CEM-SS which was infected by HIV-1 resistant to Neviparine and more specifically decreased the activity of the HIV-1 reverse transcriptase.
The most active ones inhibit the replication of HIV-1 at 3 and 6 nM.
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