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NOVEL ANTI-INFECTIOUS GLYCOMIMETIC COMPOUNDS |
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Principal Investigator : Anne Imberty
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CONTEXT
Pathogens such as Pseudomonas
aeruginosa produce a large number of protein receptors called lectins that
are able to specifically recognize carbohydrates located on human tissues.
These receptors are known to play a primary role in the infection by such
pathogens as they participate in the adhesion to host tissues through the
recognition of carbohydrate epitopes leading to the formation of biofilm which
increases the resistance to host immunity. Carbohydrates and derivatives with high affinity toward
lectins that can interfere with the adhesion process of pathogens are a promising
source of anti-infectious compounds for pathogens whom infection is based on
lectins. Such compounds consequently appear as an alternative to the use of
antibiotics which tends to be less efficient with bacteria such as Pseudomonas aeruginosa.
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