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ANTI-PRION DRUGS AND SCREENING METHOD |
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Principal Investigator: M. BLONDEL
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TECHNICAL DESCRIPTION
This invention describes a new rapid yeast-based, two-step screening test for anti-prion drugs.
Compounds isolated using this method can then be tested against mammalian prions. This new screening method allowed the identification of new compounds active against budding yeast prions which are also active against mammalian prions. Some known active molecules against mammalian prions were also evaluated in this yeast based assay. They are also active against yeast prions, which definitely validates the method.
This patent application also describes novel anti-prion compounds that the Laboratory has already identified and which are currently being protected by the CNRS.
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