CONTEXT

Lingo-1 is a transmembrane protein preferentially expressed in the central nervous system (CNS) and most specifically in neurons and oligodendrocytes. It has been shown to negatively regulate different processes: (i) the growth of neurite and axons, (ii) the survival of different neurons, (iii) the differentiation of oligodendrocytes and myelinisation. In vitro and in vivo experiments have demonstrated that the inhibition of Lingo-1 is a promising and innovative approach to treat neurodegenerative diseases such as Parkinson’s disease, multiple sclerosis, and chronic glaucoma.

Lingo-1 has 3 homologs: Lingo-2, 3, and 4. Although less studied, theses proteins might play similar roles as Lingo-1.