CONTEXT

a-amino acids present an important biological interest, because they constitute peptides and proteins. As they play an important role in the organism, the chemist seeks to synthesize structural analogous, in order to obtain new biological properties or modified peptides.

Among different strategies to develop analogous of natural amino acids, it is possible to introduce an unsaturation on the lateral chain. The unsaturation may be more or less distant from the alpha carbon. However, synthesis known in the prior art to obtain unsaturated amino acids are not adapted to the synthesis of libraries of compounds: either they are compound-specific, or involve multiple steps, or are not stereoselective, or have unsatisfying yields and more generally lack of versatility. There remains a need for the development of new methods of synthesis of libraries of unsaturated a-amino acids, and especially of g,d-unsaturated amino acids.