|
P44 MAP KINASE (ERK1) KNOCK-OUT MICE |
|
Principal Investigator : G. PAGES
|
TECHNICAL DESCRIPTION
This invention describes p44 MAPK-(Erk1) deficient mice obtained by homologous recombination in embryonic stem cells.
The p42 and p44 mitogen-activated protein kinases (MAPKs), also called Erk2 and Erk1, respectively, play a role in proliferation as well as in differentiation programs and because of their high homology (over 83%), their precise role have not yet been clearly defined.
By homologous recombination, 90% of the third exon of Erk1 was replaced by the PGK neo (neomycine resistance gene). This construction was used to generate homologous mice for this mutation.
To read more, please register or connect in the right pannel... |
