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NEW STRONTIUM-DELIVERING BIOMATERIALS FOR ANTI-OSTEOPOROTIC APPLICATIONS |
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Principal investigator : JALLOT Edouard
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TECHNICAL DESCRIPTION
This
invention describes the enhanced bioactive properties of strontium-doped
glasses. Under biological conditions, the materials form a bone-like apatite
layer at their surface with increased kinetics of reaction. This newly formed
layer allows strontium-doped glasses to harmoniously bond with the surrounding
bone tissues. Moreover, tuning both the materials’ composition and its porosity
parameters makes it possible to control the release rate of osteoinductive
ionic dissolution products, and thus the materials’ final bioactive properties.
In particular, strontium-doped glasses can deliver critical concentrations of
strontium towards their biological environment: this is a key parameter because
strontium promotes bone formation and osteoblasts replication while inhibiting
bone resorption by osteoclasts.
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