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MONOCLONAL ANTIBODY TARGETING AURORA-A KINASE |
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Principal Investigator: C. PRIGENT
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TECHNICAL DESCRIPTION
The present invention is a monoclonal antibody which targets the mammal aurora-A kinase (human and mouse). As the overexpression of aurora-A kinase has been observed in many tumors, it is very important to assess its expression.
Mice were injected with human recombinant aurora-A kinase et then killed. Spleen cells were extracted and fused with immortalized hamster cells to obtain a hybridoma. After many screening's a hybridoma was isolated that produces an antibody with a high affinity for the aurora-A kinase.
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