TECHNICAL DESCRIPTION

The present invention relates to the production and the characterization of several hybridomas which produce monoclonal anti-human GP190 receptor antibodies. Antibodies were obtained using recombinant chimeric or truncated proteins produced in a eukaryotic CHO line. The gp190 transmembrane protein belongs to the hematopoietin family of receptors and is the low affinity receptor for the cytokine Leukemia Inhibitory Factor (LIF).

The inventors also developed an ELISA assay to quantify the soluble gp190 receptor, which is naturally produced and retrieved in human biological fluids.